Epimeron uses high throughput functional genomics, including sifting through customized and proprietary databases of genomics, transcriptomics and metabolomics information, to identify the underlying genetic and biochemical machinery that allows a plant to synthesize high-value compounds. Subsequently, Epimeron utilizes gene-silencing and metabolic engineering technologies to confirm the function, roles, and interactions of previously unknown proteins and genes. New genes and process knowledge can then be deployed into recipient organisms to improve pathway performance and product yield.
What technical contribution does each partner make to a program?
Epimeron is expert in generating and mining customized genomics and metabolomics resources, and in conducting plant functional genomics experiments. We have extensive facilities to perform everything from plant husbandry to analytical chemistry. Our partners frequently prefer to provide high-throughput DNA synthesis capabilities, a proprietary organism, and the DNA insertion vector system on which their pathway is based. They often bring a preliminary knowledge base concerning the known members of their biosynthesis pathway, and may have already encountered points at which the reconstituted process is bottlenecked.
How do we integrate the efforts for maximum efficiency?
We work closely and collaboratively with our partners, sharing data and resources regularly and openly on the project. For this reason we do not work with more than one partner in a given field. Epimeron deploys its expertise in discovery work and bottleneck resolution while the partner organization contributes its high throughput synthesis capabilities, its proprietary expression system, and its scale-up capabilities and knowledge. Together our complementary capabilities make for an unbeatable package.